The first concerns the interpretation of multiple outcomes. Characteristics of Participants at Baseline, by Study Group, Participant flowchart: entry, randomization, and follow-up of participants. Annals of Family Medicine is a bimonthly peer-reviewed medical journal that was established in May/June 2003. These differences were statistically significant for duration (P = .022), but not for global severity (P = .055). Note: Central black boxes represent Cohen’s d standardized effect size; Error bars are 95% confidence intervals. Multivariate models adjusting for potential confounders yielded nonsignificant trends toward pill benefit, with 0.35, 0.62 and 0.26 days reduced duration for the 3 pill groups compared with the no-pill group. These differences were not statistically significant. Blinding was tested at an exit interview by asking participants to which group they thought they had been assigned. The target sample size of 720 participants who would finish the protocol was based on 80% power to detect 20% differences in severity-weighted days of illness (global severity) between allocation groups, assuming α = .05, proportionally stable standard deviation, and one-sided comparison. A Web-based consultation system between family physicians and nephrologists reduces the number of referrals and appears to improve treatment appropriateness among patients with chronic kidney disease. Mean illness duration for each group was 7.03 days for those in the no-pill group, 6.87 days for those blinded to placebo, 6.34 days for those blinded to echinacea, and 6.76 days for those in the open-label echinacea group. Submit your case notes and on-the-ground primary care experiences to our email@example.com team. In our case, the reverse may be true, with expectation regarding echinacea lower now than a decade ago. Editorial: Covid-19 is Harshly Testing our Capacities as Physicians and Medical Staffers - (Washington Post published 28 Marhc 2020), Ishani Ganguli, MD, MPH @IshaniG At the same time, only 1 in 5 surveyed clinicians report their fee-for-service volume is within 10% of pre-pandemic levels and nearly half (47%) endorsed the statement that despite a somewhat rosier economic picture, their clinical workforce is fragile. Area-under-the-curve global severity was calculated by first averaging morning and evening WURSS scores, then applying trapezoidal approximations.47. We need to plan reforms now. Comparing the group blinded to echinacea with the open-label echinacea group, differences were 0.42 days (95% CI, −0.28 to 1.12 days) and 22 severity points (95% CI, −19 to 63 points). Participants older than 12 years were eligible; if they were younger than 18 years, parental permission was obtained. Anyone with a history of allergic rhinitis or asthma was excluded if he or she reported itchy eyes, sneezing, cough, or shortness of breath. The Publication History of Annals of Family Medicine covers 2003-ongoing. Letter: Postacute Care Preparedness for COVID-19: Thinking Ahead - (JAMA published 25 March 2020), David C. Grabowski, PhD and Karen E. Joynt Maddox, MD, MPH Our sample was 64% female and 88% white, with 84% reporting at least some college education, and 36% reporting household incomes of $25,000 per year or less. SAS 8 (SAS Institute, Cary, North Carolina) was used to generate a single block of 804 numbers so that each of 12 cells (3 clinician groups by 4 pill groups) was represented equally. In 1955 Beecher, in his article “The Powerful Placebo,” looked at “15 studies…involving 1,082 patients.”1 Averaging results across these studies, Beecher famously claimed that “placebos are found to have an average significant effectiveness of 35.2% ± 2.2%.”1 Since then, placebo effects,2–7 expectancy,8–10 and context effects11,12 have been studied extensively and occasionally touted as therapeutic.13,14 The evidence of placebo effects is strongest for pain15–20 and depression,21–24 where multiple well-designed trials have compared placebo with no treatment. When antidepressants were first developed, there was a great deal of skepticism about whether pharmacologically active drugs could influence depression, long considered a problem of mental, not physical, health. Then came 4 highly publicized negative echinacea trials, our own in Annals of Internal Medicine (2002), followed by the Taylor et al trial in the Journal of the American Medical Association (2003),64 Yale and Liu’s in Archives of Internal Medicine (2004),65 and the Turner et al trial in the New England Journal of Medicine (2005).66 It is possible that the societal message from these negative trials reduced echinacea-related expectancy and therefore contributed to the modest effects seen here. At the time the current study was designed, several published trials of echinacea had reported benefit,37–40 whereas one, our own,41 had not. The effects of assignment to placebo-related and clinician-related treatment groups were tested using analysis of variance (ANOVA), analysis of covariance, and multivariate regression. 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