The illness was first discovered by German psychiatrist Dr. Emile Kraepelin in 1887, though the term “schizophrenia” was not used until 1910, coined by Swiss psychiatrist Paul Eugen Bleuler. By Science News Staff Dec. 17, 2020 , 2:00 PM Welcome to Science’s latest crossword puzzle, marking our 2020 Breakthrough … "This is a major breakthrough, we have found immune cells on the brain side of the endothelial wall, in greater amounts in people with schizophrenia and inflammation," says Weickert. As dimensions of psychiatric diseases cross disorder boundaries, it may be that the same pathology is … O n December 23, the FDA approved a new drug for schizophrenia, lumateperone, which was said to be a “first-in-class” medication, suggesting that its mechanism of action differed from antipsychotic drugs in current use. In the years since schizophrenia was discovered, researchers have been working hard to determine the underlying biological mechanisms that cause the illness. And it is no wonder scientists are so excited; discovering that the C4 gene may play a key role in a person’s risk of schizophrenia may open the door to strategies that prevent the illness. “We’re far from having a treatment based on this,” she adds, “but it’s exciting to think that one day we might be able to turn down the pruning process in some individuals and decrease their risk.”. The research team – including senior author Steven McCarroll, associate professor of genetics and director of genetics for the Stanley Center at Harvard – says their findings may aid the development of much-needed new treatments and preventive strategies for schizophrenia. Specifically, the team found that C4 activity was required in order for a protein called C3 to be transferred onto synapses, which acts as a signal that the synapses should be pruned. This study changes the game. Next, the team hopes to create mouse models with the human C4 variants associated with schizophrenia risk. Schizophrenia Research Breakthrough: Gene That Increases Risk Of Disorder Could Lead To New Therapies Jan 27, 2016 03:32 PM By Ali Venosa @AliVenosa Is the cause of schizophrenia just locked in our DNA? Schizophrenia Epidemiology 2017-2020 - Forecast to 2030 - ResearchAndMarkets.com. “We think this may cause the endothelial cells to extend sticky tentacles, so when the immune cells travel by some are captured. In July 2014, the Schizophrenia Working Group of the Psychiatric Genomics Consortium – including investigators from the Stanley Center – identified more than 100 areas of the human genome that are linked to the disorder. No single cause of schizophrenia has been identified, and this has prevented the development of a cure. “To find immune cells along the blood brain barrier in increased amounts in people with schizophrenia is an exciting discovery. 37th Annual Pittsburgh Schizophrenia Conference (MD67) Friday, November 13, 2020 Live-streaming Program on ZOOM Zoom links, instructions, and information will be sent out a day prior to the event. We identified immune cells as a new player in the brain pathology of schizophrenia,” said Professor Shannon Weickert. In what has been hailed a “breakthrough” in schizophrenia research, scientists from Harvard Medical School, the Broad Institute and Boston Children’s Hospital – all in Massachusetts – have discovered how a gene called complement component 4 (C4) plays a key role in schizophrenia development. These cells may transmigrate across the blood brain barrier entering the brain in greater amounts in some people with schizophrenia compared to people without the disorder.”. The current treatments for schizophrenia are designed to suppress symptoms rather than target underlying causes of the disorder. Background: Differences between people with schizophrenia and psychiatrically healthy controls have been consistently demonstrated on measures of retinal function such as electroretinography (ERG), and measures of retinal structure such as optical coherence tomography (OCT). This discovery shows that specific immune cells are in the brains of some people with schizophrenia in close enough proximity to the neurons to do damage. The results may also explain why some people with schizophrenia have a thinner cerebral cortex with fewer synapses. This article looks at some of the recent theories about…. In detail, the researchers found that the more a C4 gene structure led to the expression of the variant C4A in the brain, the greater a person’s risk of schizophrenia. ... January 13, 2020. Desperately needed vaccines against COVID-19, developed and tested at record speed, are 2020’s breakthrough. In one of the biggest breakthroughs in schizophrenia research in recent times, Professor Cynthia Shannon Weickert at Neuroscience Research Australia (NeuRA) has identified immune cells in greater amounts in the brains of some people with schizophrenia. Scientists make schizophrenia breakthrough. Explore and learn more about related title Schizophrenia Bulletin Open, an online-only, fully Open Access journal publishing in 2020. Published. NeuRA Media Department +61(0)409225447 or media@neura.edu.au, Katrina Usman +61(0)432760940 or k.usman@neura.edua.au. Different jobs. ” a severe mental health condition that causes significant disability, and 1... 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